2025 NFL Odds Week 5: Lines, Spreads for all 14 Games

NFL Week 5 kicks off Thursday night, as the Rams host the 49ers.

Here are the lines for every Week 5 matchup at DraftKings Sportsbook as of Oct. 2.

(All times ET)

2025 NFL Week 5 Odds

THURSDAY, OCT. 2

49ERS 26, RAMS 23

Spread: Rams -8.5 (49ers cover)
Total O/U: 43.5 (Over hits)

SUNDAY, OCT. 5

VIKINGS @ BROWNS

Spread: Vikings -4.5
Moneyline: Vikings -218, Browns +180
Total O/U: 35.5

BRONCOS @ EAGLES

Spread: Eagles -3.5
Moneyline: Eagles -205, Broncos +170
Total O/U: 43.5

TEXANS @ RAVENS

Spread: Texans -2.5
Moneyline: Ravens +114, Texans -135
Total O/U: 40.5

RAIDERS @ COLTS

Spread: Colts -7
Moneyline: Colts -340, Raiders +270
Total O/U: 47.5

COWBOYS @ JETS

Spread: Cowboys -2.5
Moneyline: Cowboys -135, Jets +114
Total O/U: 47.5

DOLPHINS @ PANTHERS

Spread: Dolphins -1.5
Moneyline: Dolphins -120, Panthers +100
Total O/U: 45.5

GIANTS @ SAINTS

Spread: Saints -1.5
Moneyline: Giants +100, Saints -120
Total O/U: 42.5

BUCCANEERS @ SEAHAWKS

Spread: Seahawks -3
Moneyline: Seahawks -170, Buccaneers +142
Total O/U: 44.5

TITANS @ CARDINALS

Spread: Cardinals -7.5
Moneyline: Cardinals -425, +330
Total O/U: 41.5

LIONS @ BENGALS

Spread: Lions -10.5
Moneyline: Lions -575, Bengals +425
Total O/U: 49.5

COMMANDERS @ CHARGERS

Spread: Chargers -2.5
Moneyline: Chargers -155, Commanders +130
Total O/U: 46.5

PATRIOTS @ BILLS

Spread: Bills -8.5
Moneyline: Bills -440, Patriots +340
Total O/U: 49.5

MONDAY, OCT. 6

CHIEFS @ JAGUARS

Spread: Chiefs -3.5
Moneyline: Chiefs -185, Jaguars +154
Total O/U: 45.5

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